BlisselⓇ is simply dosed for both initial and maintenance therapy
How to start and maintain BlisselⓇ1
BlisselⓇ can be started any time after the manifestation of symptoms.
Initial treatment:
One applicator-dose (1g) of vaginal gel per day for 3 weeks (suitably at bedtime).
Maintenance treatment:
One applicator-dose of vaginal gel twice a week (suitably at bedtime) is recommended. An evaluation of treatment continuation after 12 weeks should be carried out by the physician.
For initiation and continuation of treatment of post-menopausal symptoms, the lowest effective dose for the shortest duration should be used.
For oestrogen products for vaginal application of which the systemic exposure to the oestrogen remains within the normal postmenopausal range, it is not recommended to add a progestagen.
Missed doses
A missed dose should be administered as soon as remembered, unless it is more than 12 hours overdue. In the latter case the missed dose should be skipped, and the next dose should be administered at the normal time.
See the summary of product characteristics for full prescribing information.1
Precautions1
BlisselⓇ 50 micrograms/g vaginal gel must not be combined with estrogen preparations for systemic treatment, as there are no studies of safety and risks with estrogen concentrations attained in combination treatment.
Addition of a progestogen is not recommended.
Intravaginal applicator may cause minor local trauma, especially in women with serious vaginal atrophy.
For full information see the Summary of Product Characteristics.1
References
- Blissel 50 micrograms/g vaginal gel. Summary of Product Characteristics.
IE-CH-1363(1) DOP: October 2025
Adverse events should be reported. Reporting forms and information are available from HPRA Pharmacovigilance on the HPRA website www.hpra.ie.
Adverse events should also be reported to Consilient Health at drugsafety@consilienthealth.com or 012057766.
The information on this website is intended for Healthcare Professionals who practice in the Republic of Ireland only.